THOUGHTFUL is the operative word here. As dudes we like PRACTICAL, we want a give we can use and that is durable. We like useful and valuable. Women (usually, in my experience) like a gift that shows you were thinking of them or that lets them think of the people they love.
There are lots of websites where you can make mugs and other items with pictures on them. Wife LOVES them and honestly so do I. You can get a coffee mug (travel kind or ceramic) with pictures of the kids on them or pictures of you guys if you don't have kids. I have a travel mug like that and the women at the office always want to see it and they comment on how cute it is.
If she's not into that get a nice print of a collage of family pictures, there are lots of websites where you just drop in the pics and then they send you the finished print framed and on canvas. They look very nice. Just make sure you use high-res pictures so it doesn't come out all pixellated. I think Costco does them but they're super busy this time of year.
For mother's day I ordered a little board book for her to read to the baby that was pictures of the family, the baby, etc. I made it with a rhyming story because I happen to be able to write rhyming verse easily but it can just be a book of pictures.
My wife wanted an old heirloom ring reset as a necklace so she's getting that plus I'll probably give her another travel mug since she has a talent for taking them to work and never bringing them back.