I'd love to scrap athletic conferences altogether, and get back to a more regional scheduling model, with a true 16 or 32 team playoff at the end of the season.
I think the non-revenue sports will go that way soon. The travel costs for sports like women's basketball, softball, soccer, volleyball, baseball, wrestling, etc. would be much cheaper if they mostly played closer schools within driving distance. Why fly all the way to Rutgers or Maryland, when they could instead just take a bus to play KU, ISU, KSU, Creighton, Missouri, Wichita State, etc.
You could still have academic conferences like the Big Ten Academic Alliance, I don't see why athletics would have anything to do with that.