Novavax Vaccine

lost_in_office_space

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@damcde

Any thoughts on this new vaccine? Seems a more traditional tech using moth cells to generate the protein to be immunized against.

Maybe those that are hesitant with the mRNA technology could be more likely to take this vaccine?
 

steinek11

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@damcde

Any thoughts on this new vaccine? Seems a more traditional tech using moth cells to generate the protein to be immunized against.

Maybe those that are hesitant with the mRNA technology could be more likely to take this vaccine?
Yea. Real smart


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damcde

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It uses techniques that have been used in other vaccines. Insect cells are used for HPV vaccines and one of the Influenza vaccines (Flublok). Similar to viral vector technology, insect cells have been used for a few decades in the lab setting.

Then the adjuvant, which is saponin based, is also used in the Shingles vaccine (Herpes zoster).

So hopefully those two things combined will make people more confident to get it vs. the mRNA vaccines. The clinical trial results looked really good.
 

HUSKERinLA

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@damcde

Any thoughts on this new vaccine? Seems a more traditional tech using moth cells to generate the protein to be immunized against.

Maybe those that are hesitant with the mRNA technology could be more likely to take this vaccine?
The people who are hesitant to take the vaccine are ... F**K**G STUPID!

1) Untested? Bullshit! 163 Million Americans have gotten the vaccine. That's a massive test in and of itself, and it's clearly safe.

2) Long term side effects? No vaccine has ever had side effects occur after more than a few weeks, and this one has been around for months with none. You know what does have proven, extensive, and large numbers of side effects? F**kin* COVID!

Dumbf**ks!
 

IM4NUalways

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The people who are hesitant to take the vaccine are ... F**K**G STUPID!

1) Untested? Bullshit! 163 Million Americans have gotten the vaccine. That's a massive test in and of itself, and it's clearly safe.

2) Long term side effects? No vaccine has ever had side effects occur after more than a few weeks, and this one has been around for months with none. You know what does have proven, extensive, and large numbers of side effects? F**kin* COVID!

Dumbf**ks!
Well I think you have an opinion......I am not agreeing or disagreeing but you do realize it is a free country and they can choose. Call people stupid or dumb F's but hey it is a free country to choose.
 
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Jim14510

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It uses techniques that have been used in other vaccines. Insect cells are used for HPV vaccines and one of the Influenza vaccines (Flublok). Similar to viral vector technology, insect cells have been used for a few decades in the lab setting.

Then the adjuvant, which is saponin based, is also used in the Shingles vaccine (Herpes zoster).

So hopefully those two things combined will make people more confident to get it vs. the mRNA vaccines. The clinical trial results looked really good.
So you're saying this one might actually work?
 

OneBadHuskerFan

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@damcde

Any thoughts on this new vaccine? Seems a more traditional tech using moth cells to generate the protein to be immunized against.

Maybe those that are hesitant with the mRNA technology could be more likely to take this vaccine?
People "hesitant" to take the current vaccines will think of more excuses to not take any other ones. They'll just believe whatever the next round of misinformation is on their Facebook pages anyways.
 
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HUSKERinLA

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Well I think you have an opinion......I am not agreeing or disagreeing but you do realize it is a free country and they can choose. Call people stupid or dumb F's but hey it is a free country to choose.
We can also ridicule their choice and make them social outcasts. We can prevent unvaccinated morons from going to restaurants, stores, stadiums, and concert halls. We can make it criminal to pretend to be vaccinated. We can fire them for being unvaccinated. We can prevent them going to school for being vaccinated.

Yes, it's a free country, but freedom ends when it endangers others, and it's time for unvaccinated morons to pay severe consequences for their selfish endangerment of public health.

They are not just dumb f**ks, they're dangerous dumb f**ks.

#NoMercyForIdiots
 
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damcde

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So you're saying this one might actually work?

Should work as well as the mRNA vaccines.

One of the disadvantage of protein subunit vaccines historically has been that they don’t stimulate as strong of a T cell response. So they rely mostly on an antibody response. But the Shingles vaccine that uses a similar adjuvant technology induces a good T cell response. I don’t think that Novavax has released data for CD8 T cells, but I imagine it will be good.
 

IM4NUalways

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We can also ridicule their choice and make them social outcasts. We can prevent unvaccinated morons from going to restaurants, stores, stadiums, and concert halls. We can make it criminal to pretend to be vaccinated. We can fire them for being unvaccinated. We can prevent them going to school for being vaccinated.

Yes, it's a free country, but freedom ends when it endangers others, and it's time for unvaccinated morons to pay severe consequences for their selfish endangerment of public health.

They are not just dumb f**ks, they're dangerous dumb f**ks.

#NoMercyForIdiots
So your against freedom. I get it.
 

Jim14510

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Should work as well as the mRNA vaccines.

One of the disadvantage of protein subunit vaccines historically has been that they don’t stimulate as strong of a T cell response. So they rely mostly on an antibody response. But the Shingles vaccine that uses a similar adjuvant technology induces a good T cell response. I don’t think that Novavax has released data for CD8 T cells, but I imagine it will be good.
I think you missed my sarcasm there.

On a serious note explain this spin to me.

 

damcde

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I think you missed my sarcasm there.

On a serious note explain this spin to me.


I feel betrayed and embarrassed now Laughing.

This tweet is a perfect example of why I fvcking hate people sometimes. So the paper in question is looking at natural infection. So in this case, all of the viral proteins are available to make an immune response to. CD4 T cells tend to spread across different proteins relatively evenly. But CD8 T cells tend to recognize specific proteins more than others (called immunodominance). In this case, the main protein CD8 T cells bind to is the Nucleoprotein (which is not in the vaccine). However, as the tween fails to mention, the next common is the Spike protein. Additionally, there have been several papers showing that you get a CD8 T cell response from the mRNA vaccines.
 
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Jim14510

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I feel betrayed and embarrassed now Laughing.

This tweet is a perfect example of why I fvcking hate people. So the paper in question is looking at natural infection. So in this case, all of the viral proteins are available to make an immune response to. CD4 T cells tend to spread across different proteins relatively evenly. But CD8 T cells tend to recognize specific proteins more than others (called immunodominance). In this case, the main protein CD8 T cells bind to is the Nucleoprotein (which is not in the vaccine). However, as the tween fails to mention, the next common is the Spike protein. Additionally, there have been several papers showing that you get a CD8 T cell response from the mRNA vaccines.
I'm not sure that makes any more sense than the article did to me but I figured it was a bullshit spin. If nothing else you confirmed that.
 
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Oldschool1964

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I feel betrayed and embarrassed now Laughing.

This tweet is a perfect example of why I fvcking hate people. So the paper in question is looking at natural infection. So in this case, all of the viral proteins are available to make an immune response to. CD4 T cells tend to spread across different proteins relatively evenly. But CD8 T cells tend to recognize specific proteins more than others (called immunodominance). In this case, the main protein CD8 T cells bind to is the Nucleoprotein (which is not in the vaccine). However, as the tween fails to mention, the next common is the Spike protein. Additionally, there have been several papers showing that you get a CD8 T cell response from the mRNA vaccines.
You're a doctor and you hate people?
 

damcde

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You're a doctor and you hate people?

Firstly, I meant to put sometimes at the end. Secondly, I am pretty sure that there isn’t a requirement to be a doctor and like everyone. Thirdly, I am a PhD, not an MD, so my feeling towards people really doesn’t matter. Fourthly, the fact that this is what you pick out of all of this shows me what you want to believe.
 
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Oldschool1964

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Firstly, I meant to put sometimes at the end. Secondly, I am pretty sure that there isn’t a requirement to be a doctor and like everyone. Thirdly, I am a PhD, not an MD, so my feeling towards people really doesn’t matter. Fourthly, the fact that this is what you pick out of all of this shows me what you want to believe.
All this time I thought you were an MD because that's how you presented yourself. What's your PhD in?

First through Fourthly, yeah, having what I thought was a doctor saying that he hates people is out of the ordinary and is very revealing. But you're a liberal PhD, so I'm not surprised by you saying that. There's a ton more hatred on the left than there is on the right for your fellow man. So yeah, not surprising.
 

damcde

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All this time I thought you were an MD because that's how you presented yourself. What's your PhD in?

First through Fourthly, yeah, having what I thought was a doctor saying that he hates people is out of the ordinary and is very revealing. But you're a liberal PhD, so I'm not surprised by you saying that. There's a ton more hatred on the left than there is on the right for your fellow man. So yeah, not surprising.

I have never said that I was an MD. In fact I have said several times that I am a PhD and that it is in Immunology (although I study host microbe interactions).

Do you really think that all PhDs are liberals? I hate to tell you this, but political affiliations has absolutely zero to do with PhD in science. I have worked with people on the left, people on the right, in the middle, people with no political affiliation because they aren’t even from this country. And none of it matters because science doesn’t give a shvt about political affiliation like you want to try and believe it does.
 
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Oldschool1964

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I have never said that I was an MD. In fact I have said several times that I am a PhD and that it is in Immunology (although I study host microbe interactions).

Do you really think that all PhDs are liberals? I hate to tell you this, but political affiliations has absolutely zero to do with PhD in science. I have worked with people on the left, people on the right, in the middle, people with no political affiliation because they aren’t even from this country. And none of it matters because science doesn’t give a shvt about political affiliation like you want to try and believe it does.
I'm talking about YOU, a PhD liberal.

And I agree, but politics DOES give a shvt about political affiliation of the science. That's why you see grant money flowing toward "hot political topics" and minimally toward topics that don't have a political angle to them.
 

damcde

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I'm talking about YOU, a PhD liberal.

And I agree, but politics DOES give a shvt about political affiliation of the science. That's why you see grant money flowing toward "hot political topics" and minimally toward topics that don't have a political angle to them.

Once again my political affiliation has nothing to do with my PhD (which I am way more in the middle than I am on the left). I am an adult and I can separate my political feelings from my job.

What political topics impact grant money? The grant process is completely separate from rest of the federal government, with other scientists reviewing and deciding what grants to approve.